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In 1965, he was accepted into the University of Houston's pre-law program.
Several of Van Zandt's compositions were recorded by other artists, such as Emmylou Harris who, with Don Williams, had a No.
There he met fellow musicians Lightning Hopkins, Guy Clark, Jerry Jeff Walker, and Doc Watson.
His repertoire consisted mostly of covers of songs written by Hopkins, Bob Dylan, and others, as well as original novelty songs like "Fraternity Blues." In 1968, Van Zandt met songwriter Mickey Newbury in a Houston coffee shop.
They admitted him to the University of Texas Medical Branch in Galveston, where he was diagnosed with manic depression.
He received three months of insulin shock therapy, which erased much of his long-term memory.